Anticipating and preventing disease

New approaches to the world's most debilitating health conditions, such as diabetes, heart disease and obesity.

Anticipating and preventing disease

The combined cost of obesity, heart disease and diabetes to the British National Health Service is £40.4 billion per year. Depression costs £520 million to treat each year, whilst placing an £8.9 billion burden on the economy. It is thought that 23% of all deaths registered in England and Wales in 2012 were from potentially avoidable causes.

Early diagnosis of these chronic conditions could save and improve lives, and also ease their economic and emotional burdens.

  • Family check-up

Cambridge academics are developing new ways of anticipating disease and delaying its onset.  We are working towards preventive solutions for the world’s major health challenges – including heart disease, cancers and mental health.

Targeted, precise treatments

For example, by working with genomics we can understand the foundations of disease and create targeted and precise treatments. Cambridge scientists are leading the '100,000 Genomes Project', a component of the largest international collaboration ever undertaken to sequence the human genome. Our project starts by focusing on patients with rare diseases and cancers, since these conditions are strongly linked to changes in the genome.

This innovative project has the potential to create a huge genomic data repository which researchers and healthcare professionals across the country can access. Harnessing the complex large data of the human genome will enable us to better understand disease and develop individually tailored treatments.

Little girl at her check up

Personalising medicine early in life

In paediatrics we are working to maximise the impact of personalised medicine from the very start of life. By sequencing an infant’s DNA at the very start we can pre-empt and prevent major health challenges, from obesity, depression to rare diseases. This will not only save lives but will significantly reduce the cost incurred to national health systems of providing health care over an individual’s life time.

For example, we can use genomic sequencing to identify a child’s genetic predisposition to obesity. That knowledge can trigger counselling and treatments to prevent weight gain and a lifetime of health complications such as diabetes and heart disease.

How you can help

With your help we can prevent premature deaths and transform the lives of those suffering with, or susceptible to, heart disease, cancer, and mental health.

  • £2 million will help create a children’s health research institute in East Anglia which will transform paediatric care
  • £1 million will help support the 100,000 Genomes Project to deliver the benefits of genomics to individuals around the world
  • £200,000 will help support PhD students to undertake research that supports cutting-edge treatments in the field of paediatrics

Next steps

Gary Keegan

Gary Keegan

Director of Development - Cambridge University Health Partners

gary.keegan@admin.cam.ac.uk

+44 (0)1223 333167

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